Pengaruh Beberapa Bahan Aktif dalam Formulasi Rodentisida terhadap Metabolisme dan Perilaku Tikus Putih (Rattus norvegicus Wistar) di Laboratorium
Article Sidebar
bromadiolone,
coumatetralyl,
rats metabolism,
warfarin
Main Article Content
Abstract
The existence of rats often causes losses in various areas of human life, such as in agriculture, plantations, and communities. Chemical rat control is effective both indoors and outdoors, with toxic baits such as rodenticides. However, rodenticides are considered ineffective by the community and pest control services. This experiment aimed to obtain the differences in metabolism and behavior of rats due to consuming rodenticides with several types of active ingredients. The experiment was carried out from January 2020 to March 2020 at the Plant Pest Laboratory, Vertebrate Division, Department of Plant Pests, Faculty of Agriculture, Padjadjaran University. The study used a randomized block design (RBD) experimental method with 5 treatments, there were treatments without active ingredients (control), Coumatetralyl, Brodifacoum, Bromadiolone, and Warfarin rodenticide, with 6 replications. The parameters tested were rat metabolisms i.e., changes in body weight, feed and drinking consumption, feces and urine production, and rat behavior. The results showed that there were differences in metabolic effects and rat behavior due to consuming rodenticides with Coumatetralyl, Brodifacoum, Bromadiolone, and Warfarin. Four active ingredients affected decreasing body weight, feed and drink consumption, as well as the production of feces and urine, but Coumatetralyl rodenticide causes an increased drink consumption and urine production on the first day. The effect of four active ingredients in the rodenticide formulation has almost the same symptoms, and has a mechanism as an anticoagulant and an inhibitor of the central nervous system. The differences in rats behavior lie in the timing of symptoms of poisoning.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Alaydrus, H., G. Suharto, dan S. Amarwati. (2015). Analisa gambaran post mortem makroskopis dan mikroskopis organ otak dan hati pada tikus wistar setelah pemberian warfarin LD50 dan LD100. Media Medika Muda, 4, 933-947.
Amaral, E. D. C., Kedang, S. & Barimbing, M. A. (2018). Pengaruh latihan relaksasi otot progresif terhadap penurunan tekanan darah pada pasien hipertensi primer di wilayah kerja Puskesmas Sikumana Kota Kupang. CHMK Applied Scientific Journal, I, 23-27.
Cahyono, I. D., Sasongko, H., & Primatika, A. D. (2009). Neurotransmitter dalam fisiologi saraf otonom. Jurnal Anestesiologi Indonesia, 1(1):42-55.
Cox, P., & Smith, R. H. (1992). Rodenticide ecotoxicology: pre-lethal effects of anticoagulants on rat behavior. Proceedings of the Fifteenth Vertebrate Pest Confrence: Vertebrate Pest Unit, Department of Pure & Applied Zoology. United Kingdom: University of Reading. Hlm. 165-170.
European Commission. 2009. Directive 98/8/EC concerning the placing of biocidal products on the market. Assessment Report Coumatetralyl as a Product-Type PT 14 (rodenticides). Off J Eur Commun, 2-71.
Horak, K., P. M. Fisher, and B. M. Hopkins. 2018. Pharmakokinetics of anticoagulant rodenticides in target and non-target organisms. New Zealand: Springer International Publishing.
Huyck, P. 2015. Common misconceptions about mouse and rats. Associate Veterinary Information Specialist at Pet Poison Helpline. Diakses dari https://www.petpoisonhelpline.com/uncategorized/common-misconceptions-mouse-rat-poisons/.
Kurniawan, M. R., Santi, I. S., & Kristalisasi, E. N. (2017). Kajian berbagai media umpan sebagai campuran rodentisida terhadap hama tikus. Jurnal Agromast. 2, 1-6.
Lestari, S. 2016. Farmakologi Dalam Keperawatan. Bahan Ajar Cetak Keperawatan. Pusdik SDM Kesehatan. Jakarta: Kementerian Kesehatan Republik Indonesia.
Natawigena, W. D., Dono, D., & Febriana, I. (2018). Toksisitas ekstrak biji Barringtonia asiatica (Lecythidaceae) terhadap mencit putih (Mus musculus Strain DDY). Jurnal Agro, 5(2): 76-85.
Nurokhman, F. A., Basori, A., & Yuwono, M. (2018). Analisis propoksur LD50 terhadap pertumbuhan larva lalat Sarcophaga sp. dengan kromatografi gas-spektrometri massa. J Biosains Pascasarjana, 20(2): 93-104.
Permada, J. (2009). Tingkat kejeraan racun dan umpan pada tikus sawah (Rattus argentiventer Rob. & Klo.), tikus rumah (Rattus rattus diardii Linn.), dan tikus pohon (Rattus tiomanicus Mill.). Skripsi. Bogor: Institut Pertanian Bogor.
Priyambodo, S., & Supatmi, S. (2009). Pengujian laboratorium efikasi rodentisida antikoagulan (bromadiolon) terhadap tikus rumah (Rattus rattus diardii L.) di Indonesia. Seminar Nasional Perlindungan Tanaman. Bogor: Institut Pertanian Bogor.
Sinaga, C. N. L., Tobing, M. C., & Pinem, M. I. (2017). Uji efikasi rodentisida nabati daun ruku-ruku (Ocimum sanctum L.) terhadap mortalitas tikus sawah (Rattus argentiventer Robb & Kloss) di laboratorium. J Agroekoteknologi, 5, 434-443.
Switha, E. T., Anwar, C., Dalilah, D. & Ghiffari, A. (2019). Pengaruh beda tempat peletakan bangkai dengan pertumbuhan larva lalat pada tikus (Rattus norvegicus). Syifa’ Medika, 10, 46-54.
Syamsuddin. 2007. Tingkah laku tikus dan pengendaliannya. Balai Penelitian Tanaman Serealia. Prosiding Seminar Ilmiah dan Pertemuan Tahunan PEI dan PFI XVIII Komda Sul-Sel. Hlm. 179-185.
Turang, D. A. O. 2018. Aplikasi sistem pakar berbasis web untuk mendiagnosa penyakit syaraf pusat dengan metode forward chaining. Jurnal Ilmu Komputer, 5(1): 87-97.
Wagner, H., & Wolff, P. 1977. New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity. Jerman: University of Munich.
World Health Organization. 1995. The International Programme on Chemical Safety (IPCS): Anticoagulant Rodenticides. Geneva: World Health Organization.
Zailani, H. F., Sutjipto, dan S. Prastowo. 2015. Uji efektivitas rodentisida ekstrak buah bintaro (Cerbera manghas Boiteau, PIERRE L.) terhadap hama tikus. Berkala Ilmiah Pertanian, x(x): 1-5.