Pemetaan Penelitian Bioteknologi terkait Vaksin Covid-19 dan Kontribusi Indonesia: Analisis Bibliometrik selama Pandemi Covid-19 Tahun 2020

Main Article Content

Firman Fajar Perdhana

Abstract

The Covid-19 pandemic, which is currently threatening humanity, has led to research explosions all over the world, including in Indonesia. Various biotechnology studies on Covid-19 vaccine has not been mapped globally, open the potential for overlapping or research vacancies in certain areas. This study aims to analyze biotechnology research on Covid-19 vaccine and find out the contribution of Indonesian researchers in scientific publication during the Covid-19 pandemic in 2020. A total of 1777 refined documents on topics of biotechnology, Covid-19, SARS-CoV-2, and vaccine were collected from the Scopus database without any limitations. All documents were determined their bibliometric characteristics, including document type, source title, the most productive countries and institutions, top authors, and top citations. The most document type was article-based documents (911 documents). The Journal of Biomolecular Structure and Dynamics was the leading source with 80 documents. The United State of America was the most productive country with 427 publications, followed by India (383) and China (237). The Chinese Academy of Science was the most productive institution with 34 publications, followed by the Ministry of Education China and the National Institute of Health, both with 28 publications. Indonesia ranked the 26th, contributed 23 publications. Bibliometric visualization resulted in four major clusters: (1) the study related to Covid-19 patients, (2) antibody development and technology, (3) drug analysis and activity, and (4) the study of protein related to Covid-19. These findings could be useful to improve knowledge and understanding, also give direction and potential unexplored biotechnological area for further research.

Downloads

Download data is not yet available.

Article Details

Section
Articles
Author Biography

Firman Fajar Perdhana, Universitas Gadjah Mada, Yogyakarta

Program Studi Magister Bioteknologi

References

Abramo, G. (2017). Bibliometric evaluation of research performance: where do we stand?VoprosyObrazovaniya/Educational Studies Moscow, 2017(1), 112-127.

Ansori, A.N.M., Kharisma, D. V., Amaq Fadholly, A., Tacharina,M.R., Antonius, Y., & Parikesit A.A. (2021). Severe Acute Respiratory Syndrome Coronavirus-2 Emergence and Its Treatment with Alternative Medicines: A Review. Research Journal of Pharmacy and Technology Vol. 14 (10)

Anderson, R. M., Heesterbeek, H., Klinkenberg, D., & Hollingsworth, T. D. (2020). How will country-based mitigation measures influence the course of the COVID-19 epidemic? Lancet, 395 (10228), 931-934.

Artika, I. M., Dewantari, A. K., & Wiyatno, A. (2020). Molecular biology of coronaviruses: current knowledge. Heliyon, 6(8), e04743.

Bastard, P., Rosen, L. B., Zhang, Q., Michailidis, E., Hoffmann, H.-H., Zhang, Y., Dorgham, K., Philippot, Q., Rosain, J., Béziat, V., Manry, J., Shaw, E., Haljasmägi, L., Peterson, P., Lorenzo, L., Bizien, L., Trouillet-Assant, S., Dobbs, K., de Jesus, A. A., Belot, A., Kallaste, A., Catherinot, E., Tandjaoui-Lambiotte, Y., Le Pen, J., Kerner, G., Bigio, B., Seeleuthner, Y., Yang, R., Bolze, A., Spaan, A. N., Delmonte, O. M., Abers, M. S., Aiuti, A., Casari, G., Lampasona, V., Piemonti, L., Ciceri, F., Bilguvar, K., Lifton, R. P., Vasse, M., Smadja, D. M., Migaud, M., Hadjadj, J., Terrier, B., Duffy, D., Quintana-Murci, L., van de Beek, D., Roussel, L., Vinh, D. C., Tangye, S. G., Haerynck, F., Dalmau, D., Martinez-Picado, J., Brodin, P., Nussenzweig, M. C., Boisson-Dupuis, S., Rodríguez-Gallego, C., Vogt, G., Mogensen, T. H., Oler, A. J., Gu, J., Burbelo, P. D., Cohen, J. I., Biondi, A., Bettini, L. R., D'Angio, M., Bonfanti, P., Rossignol, P., Mayaux, J., Rieux-Laucat, F., Husebye, E. S., Fusco, F., Ursini, M. V., Imberti, L., Sottini, A., Paghera, S., Quiros-Roldan, E., Rossi, C., Castagnoli, R., Montagna, D., Licari, A., Marseglia, G. L., Duval, X., Ghosn, J., Tsang, J. S., Goldbach-Mansky, R., Kisand, K., Lionakis, M. S., Puel, A., Zhang, S. Y., Holland, S. M., Gorochov, G., Jouanguy, E., Rice, C. M., Cobat, A., Notarangelo, L. D., Abel, L., Su, H. C., & Casanova, J. L. (2020). Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science, 370(6515), eabd4585.

Blanco-Melo, D., Nilsson-Payant, B. E., Liu, W.-C., Uhl, S., Hoagland, D., Møller, R., Jordan, T. X., Oishi, K., Panis, M., Sachs, D., Wang, T. T., Schwartz, R. E., Lim, J. K., Albrecht, R. A., & tenOever, B. R. (2020). Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell, 181 (5), 1036-1045.E9.

Burki, T. K. (2020). Coronavirus in China. Lancet Respir Med., 8 (3), 238.

Chen, H., & Ho, Y.-S. (2015). Highly cited articles in biomass research: A bibliometric analysis. Renewable and Sustainable Energy Reviews, 49, 12-20.

Devauxa, C. A., Rolain, J.-M., Colson, P., & Raoult, D. (2020). New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? International Journal of Antimicrobial Agents, 55 (5) , 105938.

Driggin, E., Madhavan, M. V., Bikdeli, B., Chuich, T., Laracy, J., Biondi-Zoccai, G., Brown, T. S., Driggin, E., Madhavan, M. V., Bikdeli, B., Chuich, T., Laracy, J., Biondi-Zoccai, G., Der Nigoghossian, C., Zidar, D. A., Haythe, J., Brodie, D., & Beckman, J. A. (2020). Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic. Journal of the American College of Cardiology, 75 (18), 2352 - 2371.

Eck, N. J., & Waltman, L. (2020). VOSviewer Manual. Leiden: Leiden University.

Ellegaard, O. (2018). The application of bibliometric analysis: disciplinary and user aspects. Scientometrics, 116 (1), 181-202.

Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O'Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., Tummino, T. A., & Huttenhain, R. (2020). A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature, 583 (7816) , 459-468.

Harapan, H., Itoh, N., Yufika, A., Winardif, W., Keam, S., Te, H., Megawati, D., Hayati, Z., Wagner, A. L., & Mudatsir, M. (2020). Coronavirus disease 2019 (COVID-19): A literature review. Journal of Infection and Public Health, 13 (5), 667-673.

Harsanto, B. (2020). Internet of Things Innovation in Agriculture Sector: A Scientometrics Analysis. Informatika Pertanian, 29 (2) , 111-122.

Hui, D. S., Azhar, E. I., Madani, T. A., Ntoumi, F., Kock, R., Dar, O. (2020). The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-The latest 2019 novel coronavirus outbreak in Wuhan, China. International Journal of Infectious Diseases.

Kappi, M. (2020). Current Science: Bibliometric Visualization based on Scopus Database. Kelpro Bulletin, 24 (2), 11-30.

Keam, S., Megawati, D., Patel, S. K., Tiwari, R., Dhama, K., & Harapan, H. (2020). Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection. Reviews in Medical Virology, 30 (5), e2123.

Mirzaei, M., Harismah, K., Da'i, M., Salarrezaei, E., & Roshandel, Z. (2020). Screening efficacy of available HIV protease inhibitors on COVID-19 protease. Journal of Military Medicine, 22 (2), 100-107.

Muchtaridi, M., Fauzi, M., Ikram, N. K., Gazzali, A. M., & Wahab, H. A. (2020). Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2. Molecules, 25 (17), 3980.

Nainu, F., Abidin, R. S., Bahar, M. A., Frediansyah, A., Emran, T. B., Rabaan, A. A., Dhama, K., & Harapan, H. (2020). SARS-CoV-2 reinfection and implications for vaccine development. Human Vaccines and Immunotherapeutics, 16 (12), 3061-3073.

Nuryudi. (2016). Analisis Bibliometrika Islam: Studi Kasus Dokumentasi Publikasi Ilmiah di UIN Syarif Hidayatullah Jakarta. Al-Maktabah: Jurnal Komunikasi dan Informasi Perpustakaan, 15 (1), 41-55.

Rakib, A., Sami, S. A., Mimi, N. J., Chowdhurya, M. M., Eva, T. A., Nainu, F., Paul, A., Shahriar, A., Tareqf, A. M., Emon, N. U., Chakraborty, S., Shil, S., Mily, S. J., Hadda, T. B., Almalki, F. A., & Emran, T. B. (2020). Immunoinformatics-guided design of an epitope-based vaccine against severe acute respiratory syndrome coronavirus 2 spike glycoprotein. Computers in Biology and Medicine, 124, 103967.

Rattanapisit, K., Shanmugaraj, B., Manopwisedjaroen, S., Purwono, P. B., Siriwattananon, K., Khorattanakulchai, N., Hanittinan, O., Boonyayothin, W., Thitithanyanont, A., Smith, D. R., & Phoolcharoen, W. (2020). Rapid production of SARS-CoV-2 receptor binding domain (RBD) and spike specific monoclonal antibody CR3022 in Nicotiana benthamiana. Scientific Reports, 10 (1), 17698.

Sharun, K., Tiwari, R., Patel, S. K., Karthik, K., Yatoo, M. I., Malik, Y. S., Singh, K. P., Panwar, P. K., Harapan, H., Singh, R. K., & Dhama, K. (2020). Coronavirus disease 2019 (COVID-19) in domestic animals and wildlife: advances and prospects in the development of animal models for vaccine and therapeutic research. Human Vaccines and Immunotherapeutics, 16 (12), 3043-3054.

Sharun, K., Tiwari, R., Yatoo, M. I., Patel, S. K., Natesan, S., Dhama, J., Malik, Y. S., Harapan, H., Singh, R. K., & Dhama, K. (2020). Antibody-based immunotherapeutics and use of convalescent plasma to counter COVID-19: advances and prospects. Expert Opinion on Biological Therapy, 20 (9), 1033-1046.

Shen, C., Wang, Z., Zhao, F., Yang, Y., Li, J., Yuan, J., Wang, F., Li, D., Yang, M., Xing, L., Wei, J., Xiao, H., Yang, Y., Qu, J., Qing, L., Chen, L., Xu, Z., Peng, L., Li, Y., Zheng, H., Chen, F., Huang, K., Jiang, Y., Liu, D., Zhang, Z., Liu, Y., & Liu, L. (2020). Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. Journal of the American Medical Association, 323 (16), 1582 - 1589.

Shereen, M. A., Khana, S., Bashir, A. K., & Siddique, R. (2020). COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses. Journal of Advanced Research, 24 , 91-98.

Tay, M., Poh, C., Rénia, L., MacAry, P., & Ng, L. (2020). The trinity of COVID-19: immunity, inflammation and intervention. Nature Reviews Immunology, 20 (6), 363-374.

Tupan, & Rachmawati, R. (2018). Analisis bibliometric ilmu dan teknologi pangan: publikasi ilmiah di Negara-Negara ASEAN. Khizanah al-Hikmah: Jurnal Ilmu Perpustakaan, Informasi, dan Kearsipan, 6 (1), 26-40.

van Eck, N. J., & Waltman, L. (2010). Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 84, 523–538.

van Raan, A. F. (2014). Advances in bibliometric analysis: research performance assessment and science mapping. In W. Blockmans, L. Engwall, & D. Weaire, Bibliometrics Use and Abuse in the Review of Research Performance (pp. 17-28). London: Portland Press.

WHO. (2020). COVID-19 Weekly Epidemiological Update (as of 27 December 2020). Geneva: World Health Organization.

Widiasta, A., Sribudiani, Y., Nugrahapraja, H., Hilmanto, D., Sekarwana, N., & Rachmadi, D. (2020). Potential role of ACE2-related microRNAs in COVID-19-associated nephropathy. Non-coding RNA Research, 5 (4), 153-166.

Yan, Y., Pang, Y., Lyu, Z., Wang, R., Wu, X., You, C., Zhao, H., Manickam, S., Lester, E., Wu, T., & Pang, C. H. (2021). The COVID-19 Vaccines: Recent Development, Challenges and Prospects. Vaccines, 9 (4), 349.

Yang, L., Sun, T., & Liu, Y. (2017). A Bibliometric Investigation of Flipped Classroom Research during 2000-2015. International Journal of Emerging Technologies in Learning, 12 (6), 178-186.

Yeung, A. W., Tzvetkov, N. T., Gupta, V. K., Gupta, S. C., Orive, G., Bonn, G. K., Fiebich, B., Bishayee, A., Efferth, T., Xiao, J., Silva, A. S., Russo, G. L., Daglia, M., Battino, M., Orhan, I. E., Nicoletti, F., Heinrich, M., Aggarwal, B. B., Diederich, M., Banach, M., Weckwerth,W., Bauer, R., Perry. G., Bayer, E. A., Huber, L. A., Wolfender, J.-C., Verpoorte, R., Macias, F. A., Wink, M., Stadler, M., Gibbons, S., Cifuentes, A., Ibanez, E., Lizard, G., Müller, R., Ristow, M., & Atanasov, A. G. (2019). Current research in biotechnology: Exploring the biotech forefront. Current Research in Biotechnology, 1, 34-40.

Zhang, H., Penninger, J., Li, Y., Zhong, N., & Slutsky, A. (2020). Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Medicine, 46 (4), 586-590.

Zhao, J., Zhao, S., Ou, J., Zhang, J., Lan, W., Guan, W., Wu, X., Yan, Y., Zhao, W., Wu, J., Chodosh, J., & Zhang, Q. (2021). COVID-19: Coronavirus Vaccine Development Updates. Frontiers in Immunology, 11, 1-19.

Zhu, F.-C., Li, Y.-H., Guan, X.-H., Hou, L.-H., Wang, W.-J., Li, J.-X., Wu, S.-P., Wang, B.-S., Wang, Z., Wang, L., Jia, S.-Y., Jiang, H.-D., Wang, L., Jiang, T., Hu, Y., Gou, J.-B., Xu, S.-B., Xu, J.-J., Wang, X.-W., Wang, W., & Chen, W. (2020). Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial. The Lancet, 395 (10240) , 1845-1854.

Ziegler, C. G., Allon, S. J., Nyquist, S. K., Mbano, I. M., Miao, V. N., Tzouanas, C. N., Cao, Y., Yousif, A. S., Bals, J., Hauser, B. M., Feldman, J., Muus, C., Wadsworth, M. H. (II), Kazer, S. W., Hughes, T. K.. Doran, B., Gatter, G. J., Vukovic, M., Taliaferro, F., Mead, B. E., Guo, Z., Wang, J. P., Gras, D., Plaisant, M., Ansari, M., Angelidis, I., Adler, H., Sucre, J. M.S., Taylor, C. J., Lin, B., Waghray, A., Mitsialis, V., Dwyer, D. F., Buchheit, K. M., Boyce, J. A.; Barrett, N. A., Laidlaw, T. M., Carroll, S. L., Colonna, L., Tkachev, V., Peterson, C. W., Yu, A., Zheng, H. B., Gideon, H. P., Winchell, C. G., Lin, P. L., Bingle, C. D., Snapper, S. B., Kropski, J. A., Theis, F. J., Schiller, H. B., Zaragosi, L. E., Barbry, P., Leslie, A., Kiem, H. P., Flynn, J. L., Fortune, S. M., Berger, B., Finberg, R. W., Kean, L. S., Garber, M., Schmidt, A. G., Lingwood, D., Shalek, A. K., & Ordovas-Montanes, J. (2020). SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell, 181 (5), 1016-1035.e19.