Studi Awal Pembuatan Cangkang Kapsul dari Komposit Pati Garut (Maranta Arundinacea L.) dan Karagenan
Isi Artikel Utama
Abstrak
Kebutuhan bahan pembungkus makanan dan obat di Indonesia terus meningkat. Salah satu bahan pembungkus obat adalah cangkang kapsul. Cangkang kapsul berbahan dasar gelatin merupakan kapsul yang banyak digunakan. Perkembangan produk halal di Indonesia terus meningkat seiring banyaknya permintaan konsumen terhadap produk halal. Pada penelitian ini cangkang kapsul keras telah dibuat menggunakan pati garut (Maranta arundinacea L.) dan karagenan sebagai bahan utama. Ikat silang CaCl2 dan pemlatis sorbitol digunakan sebagai bahan penunjang. Karagenan yang digunakan adalah karagenan semi halus dari rumput laut merah jenis Eucheuma cottonii. Komposit dibuat dengan mencampurkan pati garut dan karagenan (2:1) serta sorbitol dengan memvariasikan konsentrasi CaCl2 (1-3%) yang dilarutkan dengan air disertai pengadukan dan pemanasan hingga homogen. Kemudian komposit dicetak menyerupai cangkang kapsul keras. Karakterisasi yang dilakukan terdiri dari uji mekanik, swelling, disintegrasi, dan spektra Infra-merah. Ketiga sampel cangkang kapsul memiliki derajat swelling pada nilai 34,19-38,59%, elongasi pada nilai 0,0332-0,0369, dan kuat tarik pada nilai 1,3647-1,2095 kN/m2. Cangkang kapsul 3% CaCl2 memiliki waktu hancur 15 menit 20 detik pada suhu 37 oC.
Unduhan
Rincian Artikel
Artikel ini berlisensi Creative Commons Attribution 4.0 International License.
Referensi
H. Ansel, Pharmaceutical Dosage Form, Edisi IX. Philadelphia.: Lipponcott Williams & Wilkins a Wolters Kluwer Business, 2011.
Hermanto, S. Saputra, and F. Rahman, “Aplikasi Metode SDS-PAGE (Sodium Dodecyl Sulphate Poly Acrylamide Gel Electrophoresis) untuk Mengidentifikasi Sumber Asal Gelatin pada Kapsul Keras,” J. Kim. Val. J. Penelit. dan Pengemb. Ilmu Kim., vol. 1, no. 1, pp. 26–32, 2016.
W. T. Wulandari and A. R. and I. M. Arcana, “Nanocellulose prepared by acid hydrolysis of isolated cellulose from sugarcane bagasse,” Ser. Mater. Sci. Eng., vol. 107, pp. 1–7, 2016.
Suryati, N. ZA, Meriatna, and Suryani, “Pembuatan dan Karakterisasi Gelatin dari Ceker Ayam dengan Proses Hidrolisis,” J. Teknol. Kim. Unimal, vol. 2, no. November, pp. 66–79, 2015.
GMIA, Gelatin Handbook. USA: Gelatin Manufacturers Institude of America, 2012.
I. Daberte, I. Barene, J. Rubens, M. Daugavietis, and N. Sazhenova, “Stability of Soft Gelatin Capsules Containing Thick Extract of Pine Needles,” vol. 47, no. Suppl 2, pp. 71–77, 2011.
G. Vilar, J. Tulla-Puche, and F. Albericio, “Polymers and Drug Delivery System,” Curr. Drug Deliv., vol. 9, pp. 1–28, 2012.
S. Nanaki, E. Karavas, L. Kalantzi, and D. Bikiaris, “Miscibility study of carrageenan blends and evaluation of their effectiveness as sustained release carriers,” Carbohydr. Polym., vol. 79, no. 4, pp. 1157–1167, 2010.
S Setiadji, et al., "Synthesis of Polydimethylsiloxane and its Monomer from Hydrolisis of Dichlorodimethylsilane", Key Engineering Materials 860, 234-238, 2020.
S Setiadji, et al., "Optimization of Polydimethylsiloxane synthesized parameters as vitreous humour substitutes", Materials Science Forum 966, 189-193, 2019.
DG Auliya, et al., "Physical characterization and in vitro toxicity test of PDMS synthesized from low-grade d4 monomer as a vitreous substitute in the human eyes", Journal of Functional Biomaterials 13 (1), 3, 2022.
S Setiadji, et al., "Synthesis and Characterization of Polydimethylsiloxane (PDMS) with Medium Viscosity via Ring-Opening Polymerization", Materials Science Forum 1028, 346-351, 2021.
DG Auliya, et al., "Synthesis of low viscosity polydimethylsiloxane using low grade of octamethylcyclotetrasiloxane", Materials Science Forum 1028, 365-370, 3, 2021.
S SETIADJI, dkk., "Uji stabilitas bahan polydimethylsiloxane", J. Material dan Energi Indonesia 9, 8-17, 2019.
DG Auliya, et al., "Use of Dichlorodimethylsilane to Produce polydimethylsiloxane as a substitute for vitreous humour: characteristics and in vitro toxicity", Journal of Functional Biomaterials 14 (8), 425, 2023.
U Fauziah, et al.,"Synthesis of Polydimethylsiloxane with hydrolysis and condensation methods using monomer of Dichlorodimethylsilane as vitreous humour substitute", Journal of Physics: Conference Series 2165 (1), 012026, 2022.
DG Auliya, et al., "Stability Test and Storage of PDMS as a Biomaterial for Vitreous Humour Substitution in Vitreoretinal Surgery", Applied Mechanics and Materials 915, 25-30, 2023.
VF Arini, et al., "Synthesis of low viscosity of polymethylhydrosiloxane using monomer of dichloromethylsilane", Journal of Physics: Conference Series 2165 (1), 012041, 2022.
W Waslaluddin, et al., "Formulation, Process, and Scale-Up Engineering of Silicone Oil", Materials Science Forum 1028, 377-382, 2021.
D SANDI, dkk., "SINTESIS DAN KARAKTERISASI MONOMER PENGGANTI OCTAMETHYLCYCLOTETRASILOXANE DARI HIDROLISIS SENYAWA DICHLORODIMETHYLSILANE', Jurnal Material dan Energi Indonesia 10 (02), 83-88, 2020.
J. Berger, M. Reist, J. M. Mayer, O. Felt, N. A. Peppas, and R. Gurny, “Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications,” vol. 57, pp. 19–34, 2004.
A. D. Katz, Polyurethane Foam. Craft Cast TM, 2008.
V. Pascalau et al., “The alginate / k-carrageenan ratio’s influence on the properties of the cross-linked composite films,” J. Alloys Compd., pp. 418–423, 2012.
D. Hasibuan, “Uji Disolusi Tablet Gliseril Guaiakolat Yang Diproduksi Oleh PT. Kimia Farma (Persero) Tbk. Plant Medan,” Universitas Sumatera Utara, 2011.
T. Funami, Y. Kataoka, T. Omoto and Y. Goto, "Food hydrocolloids control the gelatinization and retrogradation behavior of starch. 2a. Functions of guar gums with different molecular weights on the gelatinization behavior of corn starch," Food Hydrocolloids, vol. 19, no. 1, pp. 15-24, 2005.
P. Laomongkonnimit and K. Soontrapa, K., Soontrapa, “Chitosan-Zeolite Proton,” Chulalongkorn University, 2009.
R. V. Kulkarni, R. Boppana, G. Krishna Mohan, S. Mutalik, and N. V. Kalyane, “PH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: Synthesis, in vitro and in vivo evaluation,” J. Colloid Interface Sci., vol. 367, no. 1, pp. 509–517, 2012.
G. A. Towle and O. Christensen, Pectin. New York.: Academic Press, 1973.