Pengujian Iritasi dan Sensitisasi Bahan Aktif Imidakloprid dalam Formulasi Insektisida
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Imidacloprid is a synthetic chemical compound used as an insecticide product. Despite the benefits that insecticides provided in controlling plant pests and increasing crop yields, the use of insecticides was associated with side effects in humans The purpose of this study was to evaluate the active ingredient of imidacloprid 200 g/l in an insecticide formulation to ensure the safety of the pesticide for the applicator. This study was conducted based on appropriate toxicological tests and assessment based on pre-clinical tests in the form of evaluation of irritation and sensitization. The method used was descriptive quantitative based on the OECD 404, 405, and 406 guidelines for albino New Zealand rabbits and adult Dunkin Hartley albino guinea pigs. The results showed that the imidacloprid compound did not cause irritation symptoms in the eyes (cornea, iris, conjunctiva, and chemosis) and skin (erythema and edema) with a score of zero (0). In addition, the results of the sensitization test at a concentration of 12.5 - 100% did not show the formation of erythema which was indicated by a score of zero (0). In conclusion, imidacloprid 200 g/l did not caused irritation and sensitivity reactions in test animals so this compound is safe to use as an insecticide.
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Referensi
Bradberry, S. M., Proudfoot, A. T., & Vale, J. A. (2004). Glyphosate poisoning. Toxicol Rev, 23, 159–167.
Choudhury, R., Sutherland, A., Hengel, M., Parrella, M., & Gubler, W. (2020). Imidacloprid movement into fungal conidia is lethal to mycophagous Beetles. Insects, 11, 496.
Eddleston, M. & Phillips, MR. (2004). Self-poisoning with pesticides. British Medical Journal, 328, 42-4.
Direktorat Pupuk & Pestisida. (2021). Metode standar pengujian uji iritasi dan sensitisasi. Jakarta: Direktorat Jenderal Prasarana dan Sarana Pertanian, Kementrian Pertanian Indonesia.
Food & Agriculture Organization of the United Nations & World Health Organization. (2001). Report of the joint Meeting of the FAO panel of experts on pesticide residues in food and the environment and the WHO core assessment Group. Joint Pesticide residues in food. Geneva: World Health Organization.
Gunnell, D., Fernando, R., Hewagama, M., Priyangika, W. D., Konradsen, F., & Eddleston, M. (2007). The impact of pesticide regulations on suicide in Sri Lanka. International J Epidemiology, 36, 1235-42.
Jaga, K., & Dharmani, C. (2006). Ocular toxicity from pesticide exposure: A recent review. Environmental Health and Preventive Medicine, 11, 102-107.
Manuweera, G., Eddleston, M., Egodage, S., & Buckley, N. A. (2008). Do targeted bans of insecticides to prevent deaths from self-poisoning result in reduced agricultural output?. Environmental Health Perspectives, 116, 492-5.
Mckeag, D., Maini, R., & Taylor, H. R. (2002). The ocular surface toxicity of paraquat. British J Ophthalmology, 86, 350–351.
Mohamed, F., Gawarammana, I., Robertson, T. A., Roberts, M. S., Palangasinghe, C., Zawahir, S., Jayamanne, S., Kandasamy, J., Eddleston, M., Buckley, N. A., Dawson, A. H., & Roberts, D. M. (2009). Acute human self-poisoning with imidacloprid compound: a neonicotinoid insecticide. PloS one, 4, 1-5.
OECD. (2015). Test No. 404: Acute dermal irritation/corrosion, OECD Guidelines for the Testing of Chemicals, Section 4. Paris: Organisation for Economic Cooperation and Development (OECD) Publishing.
OEDa. (2021). Test No. 405: Acute eye irritation/corrosion, OECD Guidelines for the Testing of Chemicals, Section 4. Paris: Organisation for Economic Cooperation and Development (OECD) Publishing.
OECDb. (2021). Test No. 406: Skin sensitization, OECD Guidelines for the Testing of Chemicals, Section 4. Paris: Organisation for Economic Cooperation and Development (OECD) Publishing.
O’Malley, M. (2010). Hayes Handbook of Pesticide Toxicology. Amerika Serikat: Academic Press
Smith, H., Nagle, C., MacVean, C., & McKenzie, C. (2016). Susceptibility of Bemisia tabaci MEAM1 (Hemiptera: Aleyrodidae) to imidacloprid, thiamethoxam, dinotefuran and flupyradifurone in south Florida. Insects, 7, 57.
World Health Organization. (2010). WHO Specifications and Evaluations for Public Health Pesticides. Swiss: World Health Organisation.